In the present study, we seek to answer the question, what has the anti-American typology been like in the mind of the Supreme Leader of the Revolution? The research hypothesis is that since the formation of the Islamic Republic, anti-Americanism has been one of the dominant discourses of the Iranian government and society and forms the basis of anti-Americanism more than anything else, a Shiite phenomenon based on oppression, Ashura culture and hope for Mahdism. Its manifestation can be seen in the statements of Ayatollah Khamenei. The theoretical model of this research is based on Cohen and Katiznstein (2007) and in this regard, qualitative information has been collected using library resources and analyzed in a descriptive-analytical manner. The findings suggest that support for political Islam in Iran has a stronger relationship than being anti-American than Muslim religiosity itself. This connection between political Islam support and anti-American sentiment is linked to Cohen and Kutzenstein's argument that Islamism has a general negative view of the United States or what they call radical American anti-Americanism. Since the Islamic Revolution, anti-Americanism has gradually become part of the identity of the Islamic Republic. This can be seen in the statements of Ayatollah Khamenei, who has put the fight against arrogance and the United States at the forefront of foreign policy, because the anti-American foundation of the Islamic Revolution goes back more than anything to the Shiite phenomenon based on oppression and oppression. Hope for Mahdism has been formed, the least message of which can be