The connection between ethics and public policymaking does not simply mean that agents recommend individual virtues; it also requires that ethical values ​​are reflected in rules, procedures, decision-making processes, and accountability mechanisms. The main issue of this article is how ethics are transferred from the level of individual norms to the institutional level and then to the public policy cycle in the Islamic Republic of Iran. The present article, with a qualitative approach and the method of documentary and conceptual analysis, examines a targeted collection of primary Islamic sources, Persian research in the field of management and governance, and international literature on ethics and integrity in the public sector and analyzes the relationship between the concepts of justice, trustworthiness, human dignity, rights-based approach, accountability, transparency, and participation. Based on this analysis, “civilizational bioethics” is defined in this article as a proposed concept that extends ethics not only to the field of biomedicine, but also to the quality of collective life and the way of regulating public affairs, and establishes a connection between the three levels of micro, meso, and macro. At the micro level, the ethical competence and accountability of actors and the ethical evaluation of policies are of interest; at the meso level, organizational rules, conflict of interest, transparency and accountability are of interest; and at the macro level, public trust, participation and the common good are the focus.