Civilization is a type of society based on a specific worldview and attitude. As the main members of a civilization, individuals in society can, with their own free will, confront the previous civilization and establish a new civilization. The confrontation with the previous civilization takes place for various reasons, which are called the causes of the decline and decline of civilizations; and on the other hand, there are attitudes that organize the causes of the emergence of civilizations after the decline and collapse of other civilizations. In numerous verses, the Holy Quran, while telling the stories of different civilizations and the lifestyle of the people in these civilizations, explains the decline and emergence of civilizations and the causes and mechanisms of their rise and fall. In fact, these verses explain the divine traditions in the manner of the decline and rise of societies and the rotation of civilizations. Imam Khomeini, as an interpreter of the Quran, has reflected on civilizations and their rotation throughout history. According to Imam Khomeini's Quranic approach, what are the causes of civilizational change from his perspective? Relying on divine traditions in the Quran, Imam Khomeini (RA) considers the most important causes of civilizational change in different periods of history to be: oppression - justice, discrimination - equality, inefficiency - empowerment, ignorance and negligence - awakening and awareness of society, extremism - moderation, dependence - independence, insecurity - security, polytheism and disbelief - monotheism, and division - unity of Muslims.