The struggle against the system of domination and arrogance has been and is one of the lofty goals and ideals of the Islamic Revolution. And perhaps the most important enemy of this revolution is this system of domination. Familiarity with the nature of the system of domination and arrogance and its characteristics and manner of operation, especially from the perspective of the Supreme Leader of the Revolution, who is the flag bearer of the struggle against the system of domination, is one of the obvious necessities of the Islamic Revolution. Therefore, in the present article, the Supreme Leader's view on the system of domination has been examined based on his statements and letters. From the Supreme Leader's point of view, the system of domination has characteristics such as macro-politics; The enslavement of nations, the imposition of approaches on other nations, the progress of hegemons, propaganda and magnification, the threat and intimidation of nations, the defense of Israel, relying on the world's great economic enterprises, hypocrisy and hypocrisy. Cultural and propaganda, human rights, science and technology, international organization, economic tools, military intervention and security tools. The Islamic Republic's position against the domination system in the view of the leadership is the discourse of the Islamic system, shouting and exposing against oppression and domination, rejecting the domineering system and destroying domination, producing knowledge and strengthening faith, maintaining anti-American slogans and constant struggle. In his view, the struggle against arrogance and the system of domination is not unstoppable and is even one of the basic tasks and foundations of the revolution.