Over the past two decades, economic sanctions have become one of the most significant factors influencing the foreign policy and economic policymaking of the Islamic Republic of Iran. In this context, cooperation with BRICS, as one of the most prominent emerging economic blocs, has created substantial opportunities to diversify economic relations, reduce dependence on the Western-centered financial system, and strengthen economic resilience. The main objective of this study is to identify the economic policymaking model of the Islamic Republic of Iran within the framework of cooperation with BRICS to mitigate the effects of international sanctions. Using a descriptive-analytical approach based on library research, this study examines the potential of Iran–BRICS cooperation in the areas of trade, investment, banking cooperation, the use of national currencies, the development of financial infrastructure, and the strengthening of supply chains. The findings indicate that although cooperation with BRICS cannot, by itself, completely neutralize the effects of sanctions, it can reduce Iran's economic vulnerability and enhance the effectiveness of anti-sanctions policies through the development of alternative financial mechanisms, the expansion of trade in national currencies, the diversification of economic partners, and the utilization of the financial capacities of BRICS institutions.